COMPOSITION

Introduction

Avrota 20 contains atorvastatin. These are the class of drugs which are known as statins. These drugs are helpful in maintaining the lipid profile and prevents the events associated with cardiovascular diseases.

Indications

• For coronary heart disease
• Reduces stroke
• Reduce the risk of  angina
• Hyperlipidemia

Dosage

Once daily

Mechanism of action

The drug produces its action by acting as HMG Co A enzyme inhibition which converts

3-hydroxy-3-methylglutaryl-coenzyme A to mevalonate, which is a precursor of cholesterol and sterols.

Pharmcology

Absorption

After oral administration the drug attain its peak plasma concentration attains in 1-2 hrs. The approximate bioavailability of the drug is 14%. The drug availability is effected by the presence of food.

Distribution

Nearly about 98% of the drug is bound to plasma protein. The drug produces its action by its forming its metabolites.

Excretion

The drug after pharmacological action its excreted through bile. The elimination half life is 14 hrs.

Contraindications

• Hypersensitivity to any of the ingredient
• In pregnant and lactating mothers

Precautions

• Patients with hepatic dysfunction
• Increase in fasting glucose level
• In pregnant and lactating mothers