Epiride 2 Tablet contains Glimepiride. It is an anti-diabetic drug which belongs to sulphonylurea class which is long acting oral anti-diabetic drug.
- Mainly used in type 2 diabetes
- Adjunct therapy to improve hyperglycemia
Once daily in the morning after meal.
Mechanism of action
The drug stimulates the pancreatic beta cells which causes release of insulin. The drug bound to sulphonyl urea receptor in the pancreatic cells closing of potassium channel which causes release of insulin. This in turn causes lowering of blood glucose level.
After oral administration the drug peak concentration achieves in 2-3 hrs. Co-administration of the drug with food causes decrease in the concentration of the drug by 8-9%
The drug is well distributed in the body by binding protein binding about 99.5%. The drug is metabolized oxidative biotransformation by oral administration.
The drug follows renal excretion
- Patient with the history of hypersensitivity to drug
- Can cause hypoglycemia
- Increased the risk of cardiac mortality
- In pregnant patients