Cartelma-H tablet contains Telmisartan and Hydrochlorothiazide.
Telmisartan is an anti-hypertensive drug as an angiotensin II receptor antagonist. It produces its action by inhibiting the action of angiotensin II on vascular smooth muscle which in turn causes reduction in arterial blood pressure.
Hydrochlorothiazide is a thiazide diuretic which prevents the body to absorb salt which causes fluid retention.
Mechanism of action
Cartelma-H tablet is a combination of antihypertensive and diuretic.
Telmisartan blocks the actions of angiotensin II by binding it to the receptor which includes vasoconstrictor and aldosteronesecreting effects. It is having greater affinity for AT 2 receptors.
Hydrochlorothiazide is a thiazide diuretic which produces its action on renal tubular electrolyte reabsorption. It also causes increase in the excretion of sodium and chloride ions. It also causes increase in the secretion of aldosterone secretion, increases in urinary potassium loss, and decreases in serum potassium.
After oral administration the drug is well distributed into the body. Bioavailability of the drug decreases due to presence of food.
The volume of distribution of the drug is 500 L. About 99.5%of the drug is bound to plasma protein. The drug is metabolized by the enzyme cytochrome P 450.
The drug is excreted in unchanged from in urine and feces.
After oral administration about 50 - 60% of the drug gets absorbed.
About 67.9% of the drug is bound to plasma protein.
The drug follows renal excretion.