COMPOSITION

  • Pregabalin IP 75 mg
  • Methylcobalamin 750 mcg
  • ALA 100 mg

PRODUCT DESCRIPTION

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Introduction

Rejuvica - PDN Capsule contains Methylcobalamin, Pregabalin and Alpha Lipoic acid.

Methylcobalamin

It is a form of vitaminB12. It is a cobalamin which differs from cyanocobalamin. The cyanide group is replaced by methyl group in methylcobalamin. Octahedral cobalt III is present in the centre.  

Alpha lipoic acid

It is an antioxidant and is used for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. High doses of alpha-lipoic acid are approved in Germany for the treatment of these symptoms.

Pregabalin

It is an anticonvulsant drug which is mainly used for neuropathic pain. It is adjuvant for partial seizure therapy. It also effective in chronic pain disorders such as spinal cord injury or fibromyalgia.

 

Dosage

As directed by the physician

 

Indications

  • Chronic pain, post operative pain
  • Fibromyalgia
  • Neuropathic pain associated with spinal cord injury
  • Enhances memory learning
  • Support the nervous system
  • Enhance the immune system
  • Supports brain and nerve function
  • Boost the energy
  • Prevent LDL concentration
  • Prevents induction of DNA damage
  • Insomnia
  • Skin disorders

 

 

Mechanism of action

Methylcobalamin

It is the active form of vitamin B12 which a water soluble vitamin. It functions as to transfer methyl group for the regeneration of methionine from homocysteine. It acts as a cofactor for enzyme methionin synthase. In cases of anemia it causes the production of erythrocytes by nucleic acid synthesis in bone marrow.  

Pregabalin produces analgesic effect which causes relief in pain.

 

 

Pharmacology

Methycobalamin

Absorption

The drug is well absorbed in the body with peak concentration achieved after 3hrs.

Distribution

After oral administration it is well distributed

Excretion

The drug is excreted through urine.

Pregabalin

Absorption

The drug is administered in empty with peak plasma concentration attaining in 1hr. the absorption of food is decreased with presence of food. 

Distribution

The volume of distribution for the drug is 0.56L/kg. The drug is not bound to plasma protein. The drug is metabolized in the body with N-methyl pregabalin as metabolite.

Excretion

The drug follows renal excretion with half life 5–6.5 hours

Contraindications

  • Decreases the GI absorption with neomycin
  • Reduces the serum concentrations of oral contraceptives

 

 

Precautions

  • Polycythemia rubra vera
  • Megaloblastic anemia
  • Cobalt or cobalamin allergy 
  • Leber’s disease

 

 


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