COMPOSITION

  • Rosuvastatin Calcium IP Eq. To
  • Rosuvastatin 10 gm

PRODUCT DESCRIPTION

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Introduction

Suprova 10 tablet contains rosuvastatin . It belongs to the class of statins (HMG Co A reductase) which mainly use to treat  high cholesterol.

 

Indication

  • Helps in lowering bad cholesterol
  • It increases high density lipoproteins ( good cholesterol)
  • Slows atherosclerosis
  • Reduces the risk of stroke

 

Dosage

Once daily

 

Mechanism of action

The drug produces its pharmacological action by inhibiting HMG Co  A  reductase enzyme. this enzyme mainly converts 3-hydroxy3methylglutaryl coenzyme A to mevalonate which is a precursor of cholesterol. It reduces the LDL and VLDL in body.

 

Pharmacology

Absorption

After oral administration of the drug attains peak plasma concentration in 3-5 hrs. Approximately the bioavailability of the drug 20%.

 

 

Distribution

 About 88% of the drug is bound to plasma protein. The mean volume of distribution of the drug is 134 liters.

Excretion

About 90% of the drugs excreted in feces. The elimination of half concentration of the drug is 19 hrs.

 

 

Precautions

  • Hypersensitivity to any ingredient of the formulation
  • Acute renal failure

 


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