COMPOSITION

Introduction

Rejuvica-75 capsules contains pregabalin. It is an anticonvulsant drug which is mainly used for neuropathic pain. It is adjuvant for partial seizure therapy. It also effective in chronic pain disorders such as spinal cord injury or fibromyalgia.

Indication

• Anxiety disorder
• Neuropathic pain
• Seizers
• Fibromyalgia
• Epilepsy

Dosage

Two times a day or as directed by the physician

Mechanism of action

Pregabalin produces its action by binding to the high affinity voltage gated calcium channel present in CNS tissues. It causes increase in the density of GABA transporter protein which increase its functional rate.

Pharmacology

Absorption

After oral administration the drug achieves its peak plasma concentration in an hour. Presence of food effects the action of drug. The oral bioavailability of the drug is about 90%.

Distribution

The drug after oral administration does not bound to plasma protein. The approximate volume of distribution is 0.56L/kg. The drug can cross blood brain barrier and placenta.

Excretion

The drug follows renal excretion with renal clearance of 73ml/min.

Contraindication

• In patients with hypersensitivity to any of the ingredient
• Can cause angioedema

Precautions

• Can causes swelling on face, mouth and neck
• Angioedema
• Hypersensitive reaction
• Sudden withdrawal of therapy cause suicidal behaviour