Rejuvica – PDN Capsule contains Methylcobalamin, Pregabalin and Alpha Lipoic acid.
It is a form of vitaminB12. It is a cobalamin which differs from cyanocobalamin. The cyanide group is replaced by methyl group in methylcobalamin. Octahedral cobalt III is present in the centre.
Alpha lipoic acid
It is an antioxidant and is used for diabetes and nerve-related symptoms of diabetes including burning, pain, and numbness in the legs and arms. High doses of alpha-lipoic acid are approved in Germany for the treatment of these symptoms.
It is an anticonvulsant drug which is mainly used for neuropathic pain. It is adjuvant for partial seizure therapy. It also effective in chronic pain disorders such as spinal cord injury or fibromyalgia.
As directed by the physician
- Chronic pain, post operative pain
- Neuropathic pain associated with spinal cord injury
- Enhances memory learning
- Support the nervous system
- Enhance the immune system
- Supports brain and nerve function
- Boost the energy
- Prevent LDL concentration
- Prevents induction of DNA damage
- Skin disorders
Mechanism of action
It is the active form of vitamin B12 which a water soluble vitamin. It functions as to transfer methyl group for the regeneration of methionine from homocysteine. It acts as a cofactor for enzyme methionin synthase. In cases of anemia it causes the production of erythrocytes by nucleic acid synthesis in bone marrow.
Pregabalin produces analgesic effect which causes relief in pain.
The drug is well absorbed in the body with peak concentration achieved after 3hrs.
After oral administration it is well distributed
The drug is excreted through urine.
The drug is administered in empty with peak plasma concentration attaining in 1hr. the absorption of food is decreased with presence of food.
The volume of distribution for the drug is 0.56L/kg. The drug is not bound to plasma protein. The drug is metabolized in the body with N-methyl pregabalin as metabolite.
The drug follows renal excretion with half life 5–6.5 hours
- Decreases the GI absorption with neomycin
- Reduces the serum concentrations of oral contraceptives
- Polycythemia rubra vera
- Megaloblastic anemia
- Cobalt or cobalamin allergy
- Leber’s disease