Rofmin SR 5002018-08-25T05:12:56+00:00

rofmin sr 500

COMPOSITION

  • Metformin 500 mg
  • Sustained Release Form

PRODUCT DESCRIPTION

rofmin sr 500

Introduction

Rofmin SR 500 Tablet contains metformin. It is also an oral antidiabetic drug which belongs to biguanide class which is the first line treatment for type 2 diabetes mellitus. It causes suppression of glucose production by liver.

Indication

  • First line treatment for type 2 diabetes
  • Metformin is used in pre-diabetes
  • PCOS (polycystic ovary syndrome)
  • Gastrointestinal diabetes

Dosage

Twice daily or as directed by the physician

Mechanism of action

It decreases gluconeogenesis in liver and also decreases the intestinal absorption of glucose. It also improves the sensitivity of insulin.

Pharmacology

Metformin

Absorption

In fasting condition of the patients, the drug bioavailability is about 50% to 60%. Food decreases the absorption of drug.

Distribution

The volume of distribution is 654±358 L. It rarely bonds to plasma protein. It does not follow hepatic metabolism.

Excretion

It is excreted in unchanged form in urine

Contraindications

  • Use is contraindicated in pregnant patient
  • In lactating mothers
  • Renal dysfunction
  • Patient undergoing radiological studies
  • Acute or chronic metabolic acidosis

Precautions

  • Renal and hepatic impairment
  • Avoid alcohol consumption
  • Hypoglycemic episodes
  • Lung and liver disease